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Higher doses reached that plateau later in the trial. In a 112-week step-down trial, participants maintained 21.9% loss on the top dose, 16.6% after stepping down to 5 mg, and 9.9% on placebo

Established that NAMPT-mediated NAD+ biosynthesis is regulated by CLOCK/BMAL1 circadian transcription factors, creating a circadian oscillation of NAD+ that drives SIRT1, SIRT3, and SIRT6 activity

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In a 12-week randomized clinical trial involving 300 obese adults, participants receiving 1 mg daily of AOD-9604 lost an average of 2.6 kg (approximately 5.7 pounds) compared to 0.8 kg (1.8 pounds) in the placebo group