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GLP-1 (Glucagon-like peptide-1) medications, including Liraglutide and Semaglutide, are used primarily for the management of type 2 diabetes and weight loss

Inhibition of SGLT2 reduces sodium reabsorption in the proximal tubule and enhances Na + delivery to the macula densa, promoting finally the TGF activation with consequent afferent arteriole vasoconstriction and reduction of the single-nephron-glomerular-filtration-rate ( Figure 1 )

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Whether due to cost, availability, tolerability or personal choice, GLP-1 medications are not always accessible to people who may benefit from them

GIP increases insulin receptor affinity and cellular sensitivity in adipocytes