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The glucose-dependent mechanism reduces hypoglycemia risk when combined with metformin, SGLT2 inhibitors, or thiazolidinediones

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The research findings stimulated the study of GIT in this population and several alterations were identified, such as: Low activity of digestive enzymes responsible for hydrolyzing carbohydrates and proteins, gastroesophageal reflux, food allergy and dysfunction of secretin production [79,81,82]