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And what lessons from other therapeutic areas can be integrated here to go further than we might if we remained narrowly focused on metabolism alone? Much of todays innovation pipeline builds on combining GLP-1 with other gut hormones
Interestingly, the discovery of poly-agonist drugs that activate multiple gutbrain pathways promises to further transform the management of metabolic diseases besides type 2 diabetes, including obesity and non-alcoholic fatty liver disease (NAFLD) [6,7,8]
However, in the exenatide treatment group, the primary outcome rate was 61.2% (n=170), compared to 56.7% in the standard treatment group (n=171), with an adjusted ratio of 1.22 [95% CI, 0.79-1.88] (P=0.38)., which meant that the proportion of subjects who achieved the desired effect in exenatide treatment group was higher (110)
That is in common with a number of other GLP-1 drugs
Phenformin In the late 1950s, Phenformin was introduced in the United States for the treatment of non-insulin-dependent (NIDDM) and was 50 times more powerful than metformin
The result is a bioavailability profile sufficient to drive clinically meaningful weight loss, something the scientific community long considered impossible for peptide-based GLP-1s
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