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There is limited clinical evidence available

doi: 10.3390/antiox10121912

Treatment may include: (7) Blood transfusion

This is not a comfortable middle ground

Setting realistic goals: Define specific objectives (pain reduction, return to specific activities, healing verified on imaging) rather than vague "feel better." Understand realistic timeline (weeks for soft tissue, months for bone, months to years for cartilage) preventing premature disappointment

Without rigorous, peer-reviewed clinical trials, the long-term behaviour of these substances within the body remains less clear than that of MHRA-approved medications