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A total of 50 participants (men and women, 3560 years of age) with dry skin, skin moisture content of 49% or less, or crows feet greater than grade 3 were tested for 12 weeks in this double-blind, randomized, parallel, placebo-controlled study (equal numbers of subjects were in the APCP or placebo groups)

Nausea: Some individuals may experience mild nausea after receiving an injection

No tolerance development to the lipolytic effects was noted in these studies, suggesting that unlike beta-2 agonists (which rapidly desensitize their receptors), beta-3 receptor activation may not produce the same downregulation pattern