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The drug inhibited inflammatory cytokines and T cell infiltration in both the ocular surface and lacrimal glands

In HSCs, sirtuin 3 (SIRT3) preserves genomic stability and mitochondrial integrity, delaying cellular aging by increasing superoxide dismutase 2 (SOD2) activity and reducing oxidative stress

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The intracellular ROS detection revealed that when the ROS-sensitive thioketal linkage cleaved in the presence of tumor microenvironment, the cinnamaldehyde moiety was released, triggering the mitochondria to regenerate additional ROS (Fig

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