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All mice were observed daily for signs of vaginal opening (VO) which reflects sexual maturation due to increased ovarian activity and estradiol levels and is commonly used as a proxy for pubertal onset [103]

Novo Nordisk announced FDA acceptance of their New Drug Application (NDA) for a 25 mg oral version of Wegovy for two new indications: (1) chronic weight management in adults living with obesity or who are overweight with at least one comorbid condition, and (2) to reduce the risk of MACE in adults with overweight or obesity and established CVD

doi:10.7554/eLife.13185