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Patients initiating semaglutide therapy should anticipate gradual changes in appetite and eating patterns, typically beginning within the first two to four weeks of treatment

J Neurochem (2019) 148(3):42639

Therefore, enhanced glutaminolysis might eventually contribute to the initiation and progression of cancer by stimulating cell growth via the mTORC1 pathway and enhancing aerobic glycolysis while disrupting the proper elimination of misfolded proteins, damaged DNA and organelles through the inhibition of autophagy and the DNA damage response 166

Side effects, particularly nausea, are more pronounced than single-agent therapy but manageable with proper strategies

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These effects are manageable with dietary adjustments, hydration, and fiber intake