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Optimized LC-MS/MS parameters for the analysis of eicosanoids are in accordance with previous research ( Inhibition of Cyclooxygenase 1 (COX-1) and Cyclooxygenase 2 (COX-2) in Cell-Free Assays Cyclooxygenase (COXs) can convert AA to PGG 2 , and further reduce PGG 2 to PGH 2

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For autoimmune applications, where the margin between helpful modulation and harmful stimulation may be narrow, getting these details right matters even more than in other contexts