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Unlike GLP-1 agonists that reduce appetite or growth hormone peptides that stimulate lipolysis, the compound addresses fat metabolism at the enzymatic level: it removes the molecular governor that locks adipocytes into a low-energy-expenditure state, potentially restoring normal metabolic function in fat tissue where NNMT is overexpressed

[DOI] [PubMed] [Google Scholar] 15.Nijst T.Q., Wevers R.A., Schoonderwaldt H.C., Hommes O.R., De Haan A.F

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The effect was most pronounced in visceral (abdominal) fat, and lean mass was preserved entirely