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However, we believe that this paradigm could be used well in the future to study multiple aspects of feeding regulation in obesity models with dysregulated feeding behaviour (i.e., in animals that overeat during ad libitum feeding)

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Limitations include: Enzymatic and chemical degradation Poor membrane permeability Comparatively large molecular size When a peptide like epithalon is unmodified, bioavailability may be less than 1%

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Journal of Clinical Sleep Medicine, Volume 17, Issue 2, February 1, 2021