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Two studies in particular deserve close examination because they represent the best available evidence for making clinical decisions

doi: 10.1002/jnr.24331 243 SunJ.WangF.LingZ.YuX.ChenW.LiH.et al

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The GRADE trial suggested no difference in cognitive decline across insulin glargine, the DPP4 inhibitor sitagliptin, the sulfonylurea glimepiride, and the GLP1 receptor agonist liraglutide, but the mean age was 57.1 years, and SGLT2 inhibitors were not examined [54]

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