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The mitochondrial pyruvate carrier (MPC) regulates the entry of glycolytic pyruvate into the mitochondria, serving as a key node linking glycolysis to OXPHOS [51]

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Zepbound is also approved to treat moderate to severe obstructive sleep apnea in adults with obesity

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Furthermore, in individuals with a history of alcoholism, fasting, or liver disease, even therapeutic doses of APAP can cause liver injury