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However, these agents often lack selectivity, potentially causing unnecessary damage and apoptosis in normal cells (Marcus et al., 2018

Anti-drug antibodies may develop against therapeutic peptides, particularly those that differ structurally from endogenous human peptides

Research Overview Retatrutide is a next-generation multi-agonist peptide that engages GIP, GLP-1 and glucagon receptors simultaneously

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While these effects are generally manageable, they represent more pronounced GI side effects than observed with AOD-9604