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2.2 Dysregulation of neurotrophic support Brain-derived neurotrophic factor (BDNF) and its high-affinity receptor, tropomyosin receptor kinase B (TrkB), constitute a signaling axis fundamental to neuronal survival, differentiation, and synaptic plasticity within the central nervous system (Numakawa and Kajihara, 2025)

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Although tools, such as computerized in-office assessments with on-road evaluation and virtual reality-based driving tests have been developed, practical and easily deployable screening methods are still lacking [19, 145]