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L-carnitine (300 mg/kg)-treated group illustrated fewer numbers of degenerated neuronal cells, as well as mild gliosis and perivascular oedema (Fig

2025;doi:10.1001/jamaneurol.2025.0360

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Also, mTORC1 activates the ribosomal protein S6 kinase beta-1 (S6K1) and the eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1), promoting the translation of MCL-1 mRNA on ribosomes and the synthesis of Mcl-1 [301]

Further mechanistic studies in TgSwDI mice indicate that OC also activates the ApoE-dependent amyloid clearance pathway and increases A-degrading enzymes, allowing a multifaceted reduction in cerebral amyloid burden (80)