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Abbas et al., 2023b) and is related to its cytotoxic effects (Tunali-Akbay et al., 2010

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Moreover, the body weights of MTX and HPE-treated group recorded a highly significant increase ( p 0.001) at the fifth day compared with MTX-treated animals within the same period (5 days), but it was still showing a significant decrease at p 0.05 compared with the control animals