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RVs are from LC (green), VLC (pink), HARPS03 (cyan), UVES (yellow), HARPS15 (blue) and HARPS20 (pink)

The resulting citrullinated proteins induce the production of anti-cyclic citrullinated peptide autoantibodies, amplifying autoimmune damage [405, 406]

Considering all these data together, it is reasonable to assume the existence of an RBC-Hb self-assembly system and a spontaneous system of drug release by RBCs after oral or intravenous administration of this drug, which provided a new understanding of the discrepancy between the high tissue concentration and extremely low plasma concentration of berberine

This resistance allows for prolonged exposure to GLP-1, resulting in sustained physiological effects

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