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During the tests, rats and shrews administered with GEP44 showed no signs of nausea or vomiting, possibly due to the activation of multiple receptors canceling out the intracellular signaling pathway responsible for those symptoms

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However, according to data nausea, vomiting, diarrhea, and constipation affect 40%70% of patients on GLP-1 medications

Gouet P, Robert X, E

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