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Acute heavy intake (5+ drinks in one session) suppresses nocturnal GH secretion for 2448 hours and reduces hepatic IGF-1 production for 4872 hours post-consumption

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Although still uncorroborated by well-defined translational substantiation, the GLP1-RAs-induced upregulation of ACE2 could ameliorate lung injury, antagonizing the reduction of ACE2 expression levels that are hallmarks of SARS-CoV-2 infection progression [65] and precluding the over-activated immune response critical for acute respiratory distress syndrome [66] (Figure 1)

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To confirm that these calcium dynamics were specific to cocaine-seeking behavior, a separate group of TH-Cre rats was allowed to self-administer saline before undergoing extinction and subsequent reinstatement test sessions