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In a multicellular organism, TLs are highly heterogeneous across different tissues and cell types depending, at least partly, on the tissue-specific proliferation rate, but they generally tend to decrease with age in all proliferating tissues (Demanelis et al., The size of critically short (uncapped) telomeres may be stabilized by telomerase, a reverse transcriptase enzyme that can elongate chromosome ends de novo

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These spots are permanent and become bigger over time

For example, in a rat sciatic nerve injury model, Melanotan 2 significantly enhanced the recovery of sensory function, especially at specific doses (such as 20 g/kg/48h)

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