This mechanistic distinction is the focus of ongoing preclinical research
However, a systematic review and meta-analysis found this is not clear cut, as indicated by a number of other studies that failed to replicate these data [126]
10.1016/j.pneurobio.2016.10.001 Prog
Today, GLP-1 analogues of different generations are available, both short- and long-acting, with different structures and durations of effect, making it possible to tailor therapy to the needs of patients with type 2 diabetes and obesity
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