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Limited Oral Bioavailability The poor oral bioavailability of most peptides necessitates injectable administration, which can affect patient acceptance and adherence

Some centers are well-equipped and medically supervised, while others vary in structure and transparency

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10.1038/s41418-019-0351-4 134

Response: We acknowledge commenters' concerns on the proposed CY 2026 market basket of 2.4 percent, including the challenging financial landscape in which rural hospitals operate