The original research program began during the 1980s at the University of Arizona, where scientists were searching for a sunless tanning method that could help protect people with fair skin from skin cancer
90-Day On / 30-Day Off This is perhaps the most widely reported cycling pattern: Use Dihexa daily for approximately 90 days (13 weeks) Discontinue completely for 30 days (4 weeks) Repeat the cycle Rationale: Allows receptor sensitivity to reset and minimizes tolerance No scientific evidence supports this particular cycle length 5-Days-On / 2-Days-Off A shorter cycle pattern used by some: Take Dihexa for 5 consecutive days, then skip 2 days Repeat weekly Provides more frequent breaks without long discontinuation Anecdotally reported to maintain responsiveness Continuous Use Some community members report continuous daily use without cycling: Effects may be maintained or may plateau Risk of tolerance development is unknown Long-term safety of continuous use is not established Important Note on Cycling The concept of receptor tolerance and its mitigation through cycling is theoretically grounded in neuropharmacology
(eds) Oral and Maxillofacial Surgery for the Clinician
ACE2 is also significantly expressed in other tissues like vascular endothelium, heart, kidney, intestine, and nervous system [11]
For example, extremely low-frequency EMFs (ELF-EMFs) have been shown to inhibit neuronal activity, reducing seizure frequency in epilepsy (Wang et al., 2024)
To further investigate tumor angiogenesis markers for breast cancer for evaluation of anti-angiogenic therapy efficacy, promoting vascular normalization may be a necessary prerequisite for reversing drug resistance
