Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation
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doi: Wilding JPH, Batterham RL, Calanna S, et al
GLP-1 receptor agonists, such as Wegovy, Ozempic, and Mounjaro, have gained significant attention for their effectiveness in weight loss and their potential to reduce obesity-related health conditions
These include side effects, risk of nutrient inadequacies, muscle, and bone loss, high costs, frequent discontinuation, and weight regain
Human GLP-1 was rapidly degraded by DPP-4, while EX showed prolonged kinetics because of its resistance to proteolysis of DPP-4 (48)