Additionally, it is a single-arm study without a comparator group, which limits its ability to draw direct comparisons
For many people, it works best as one part of a larger plan that includes balanced eating, regular movement, sleep, and ongoing support
The 17% average weight loss by week 24 translates to meaningful reductions in cardiac workload
The October 2025 analysis published in the Journal of the Endocrine Society (abstract SUN-659, with full peer-reviewed article at PMC12544991) reported retatrutide at a mean absolute reduction of 16.34 kg and 23.77% body weight versus 11.82 kg and 16.79% for tirzepatide, an indirect advantage in retatrutides favour 20
Losing 30 pounds could take anywhere from several months to over a year, depending on individual factors
Molecular Weight:711.9g/mol