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This suggested the possibility of an association between the multisystemic inflammatory syndrome in children (MIS-C), SARS-CoV-2 infection and acute appendicitis.24 We present the cases of 3 children with an unremarkable prior history that developed acute appendicitis in the context of MIS-C

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Rather than alterations in single components, the impact on depression pathobiology may be due to the net effect of different dysregulations and interrelated compensatory mechanisms in such a complex network, which could be fully unraveled only by further functional and mechanistic studies

However, the shifting in the figures will likely put a cap on how this method could be used daily in medical activities [113]

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