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The passage of molecules larger than 800 Da is restricted to a series of specialized transporters, which dynamically regulate the transcellular in- and efflux of substrates (Obermeier et al., 2013)

More is not better, and overdosing carries risk

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Common causes include: Aging: As we get older, cartilage wears down, leading to conditions like osteoarthritis (Wang et al., 2021)

What we dont want to see happen is patients going into the emergency department for prescription renewals

Systematic administration of IGF-1 has been shown to enhance healing in collagenous extracellular matrices