Metformin works by decreasing glucose production in the liver and reducing absorption of glucose by the intestines
25 mg/day oral Tirzepatide 15 mg/week Retatrutide 12 mg/week Liraglutide 3.0 mg/day Factor Peak trial weight loss Semaglutide -14.9% at 68 wks (STEP 1) Tirzepatide -22.5% at 72 wks (SURMOUNT-1) Retatrutide -28.7% at 68 wks (TRIUMPH-4) Liraglutide -8% at 56 wks (SCALE) Factor FDA status (June 2026) Semaglutide Approved (T2D, obesity, CVD, MASH, CKD, oral) Tirzepatide Approved (T2D, obesity) Retatrutide Investigational - Phase 3 Liraglutide Approved (Saxenda obesity, Victoza T2D) Factor CV outcomes data Semaglutide Yes - SELECT (20% MACE drop) Tirzepatide SURPASS-CVOT ongoing Retatrutide TRIUMPH-3 ongoing Liraglutide Yes - LEADER (13% MACE drop) These compounds are not interchangeable
Frequently asked questions How should this combined vial be reconstituted
Endothelial dysfunction in diabetes mellitus: role in cardiovascular disease pathogenesis
They may only seek help during an emergency
A spokesperson for Eli Lilly, the manufacturer of Mounjaro and Zepbound (tirzepatide), told The Post that the medications include robust, FDA-approved warnings. Patient safety is Lillys top priority, and we actively monitor, evaluate and report safety information for all our medicines, they said in a statement
