The transient receptor potential (TRP) channels on the cell surface allow Ca 2+ influx to initiate the NF-B-dependent inflammatory responses, which can be triggered by environmental irritants such as inflammatory cytokines and pathogens [61,62,63]
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So, a deficiency not only causes neurological problems, but it makes you anemic
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doi:10.1186/s12959-016-0119-8 [PubMed] 65
So, while there are upper limits that people should stay below for B vitamins, its pretty unusual for anyone to reach them
