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The catalytic Cys groups in thiol have lower pKa values of 5.57.4, which in turn act as a H 2 O 2 -sensing center and react with H 2 O 2 under physiological conditions (Chae et al., 2023)

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Retatrutide (development code LY3437943 ) is a single synthetic peptide developed by Eli Lilly that acts as a triple agonist at three receptors simultaneously: the glucose-dependent insulinotropic polypeptide (GIP) receptor, the glucagon-like peptide-1 (GLP-1) receptor, and the glucagon receptor

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