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At 2 mg per injection, it falls far below the therapeutic oral doses of 500-3000 mg daily that have been studied for various conditions

doi: 10.1186/s13195-021-00813-8 33 Tahami MonfaredAATafazzoliAYeWChavanAZhangQ

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Obesity can cause hypertension, Type 2 diabetes and high cholesterol, which lead to greater risks of things like stroke and heart attacks.

Clin Ther 43:112-122e1 Golay A, Laurent-Jaccard A, Habicht F et al (2005) Effect of orlistat in obese patients with binge eating disorder

Injection site reactions occurred in 5 to 15% of retatrutide trial participants and are generally mild, resolving within 24 to 72 hours