Under stress conditions (temperature changes, agitation, air-liquid interface exposure), semaglutide molecules can stick together, forming dimers, trimers, and larger aggregates
Unsurprisingly, such patients typically have a more guarded prognosis than age-matched, normal weight peers, since obesity is accompanied by an increased pregnancy loss rate
Patients with a personal or family history of medullary thyroid cancer should avoid this combination, as GLP-1 agonists carry a black-box warning for that condition
Hyperprolactinemia and bone
Obesity and cardiovascular disease: Pathophysiology, evaluation, and effect of weight loss: An update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism
Yu X, Chen S, Funcke JB, et al