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Studies have shown that cells with reduced NAD+ levels exhibit significantly impaired DNA repair capacity, with 40-60% reductions in repair efficiency when NAD+ levels decrease by 50%

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As we indicated in the CY 2026 OPPS/ASC proposed rule, we still believe that, by now, hospitals have largely developed standardized processes and procedures for encoding the existing estimated allowed amount and general data elements, like hospital license number, in the MRF and that modifying their existing processes to include the four new data elements related to the proposed allowed amounts and hospital NPI would not entail a significant amount of additional work for hospitals