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If you notice the stopper surface deteriorating or if the vial no longer holds vacuum (you don't hear a slight hiss when first puncturing), replace the vial or transfer contents to a fresh sealed container

Methods Protocol The study protocol for the present systematic review was first published 23 January 2021 in the PROSPERO database, Protocol deviations The following deviations from the initial protocol were necessary and were amended in a protocol update: the search strategy was updated to include Embase and Cochrane

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Please let the school know as well, as they can disinfect the classroom, she says