Glutathione in brain disorders and aging
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It has been reported to enhance glutathione levels and the overall activities of antioxidant enzymes
In the murine model of lipopolysaccharide (LPS)induced ALI, severely impaired FAO in alveolar EpiCs participated in the inflammatory response and lung injury, which might be attributed to the decreased expression of key mediators involved in FAO, such as CPT1A, and could partly be counteracted by treatment with a PPAR agonist, fenofibrate ( CPT1A aggravated EC apoptosis and lung injury, while treatment with L-carnitine attenuated the pathological changes ( 3.1.3 Bronchial Asthma As another common chronic respiratory disease, the pathophysiology of bronchial asthma (or asthma) is orchestrated by various inflammatory cells and mediators in close communication with airway structural cells, including EpiCs and smooth muscle cells (SMCs)
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Almost all inflammatory diseases exhibit evidence of enhanced oxidative stress (18)