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As demonstrated by oxyntomodulin, a weak endogenous agonist for GLP-1 receptor and glucagon receptor, a strategy that simultaneously stimulates both GLP-1 and glucagon receptors can reduce food intake while increasing energy expenditure, synergistically enhancing weight loss [105-107]
Other injectable GLP-1s may also be prescribed off-label for weight loss, even though they are FDA-approved for conditions such as type 2 diabetes
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Eating smaller meals and avoiding heavy or greasy foods may help
To overcome postnatal developmental complications and determine the cell-specific role of IGF-1R, we generated rod photoreceptor-specific IGF-1R KO (abbreviated as rod Igf-1r / ) mice