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En una cohorte de 3.731 pacientes se observaron prdidas de peso de 5, 10 y 15% en 63, 33 y 14%, respectivamente, a las 56 semanas de iniciar el tratamiento (27, 11 y 4% con placebo)69, o de 6% a las 56 semanas en pacientes que ya haban perdido previamente otro 6% mediante dieta hipocalrica y ejercicio70