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Data presented at the 61st Annual Meeting of the European Association for the Study of Diabetes (EASD) 2025, a few months back, have provided new insights into the potential role of metformin within a GLP-1 RA-based regimen continuum, with findings that extend beyond glycaemic outcomes into territory that carries greater clinical weight

Early shifts support repair, strengthen resilience, and set the stage for what comes next

Calorie restriction decreases murine and human pancreatic tumor cell growth, nuclear factor-B activation, and inflammation-related gene expression in an insulin-like growth factor-1-dependent manner

PARPs, located in the nucleus, mediate many biological processes, including DNA repair, transcriptional regulation, and metabolism (41, 45), by transferring long chains and branches of ADP-ribosyl polymers to their protein substrates

Recently, Beltro et al

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