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Furthermore, microbiota composition varies depending on its localization in the gastrointestinal system

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The evidence base is not human clinical data, but it is far more extensive than KPV's body of work

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But that's going to be a work in progress

Phase 2 and mechanistic studies report reduced hunger perception, delayed gastric emptying, and effects on postprandial glucoregulatory hormones consistent with amylin signalling, though exact glucagon findings should be attributed to the original trial reports [2]