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Since its first description in the peer-reviewed literature by Neelakantan et al
In practice, this involves giving an initial 4 g IV infusion of pyridoxine, followed by repeated 1 g IM injections every 30 minutes until the total matched dose is reached
Flick the barrel and push bubbles to the needle tip, then expel them before injecting to ensure accurate dose delivery
When vial-size variants exist, they remain separate because vial strength, concentration, and syringe-unit calculations can differ
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