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2.3.1 Background ALS is a serious and progressive disease that damages both the upper and lower motor neurons, which are the nerve cells that control voluntary muscle movement
Glutathione, also referred to as GSH, is an antioxidant that occurs naturally in all body tissues
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Its levels can be depleted, and replenishing them with standard supplements is less effective if your body isn't absorbing them well
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While the PARS1 inhibitor halofuginone exhibited toxicity, its optimized derivative DWN12088 demonstrated improved safety and efficacy in preclinical models and is currently under clinical investigation for IPF [143]
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