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Metabolite intermediates or other specific macromolecules leverage porins and outer membrane transporters (TOM) to cross the mitochondrial membrane into the inner mitochondrial space (IMS) or mitochondrial matrix, regulating the TCA cycle and oxidative respiratory chain [20]

doi:10.1152/physiol.00023.2008 Polonis K, Becari C, Chahal CAA, et al

Targeted probiotic strains and supportive nutrients help address these drivers rather than treating digestion in isolation

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Efficacy and safety of once-weekly semaglutide versus exenatide ER in subjects with type 2 diabetes (SUSTAIN 3): A 56-week, open-label, randomized clinical trial

Longer treatment typically equates to higher overall costs