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Based on Phase 2 trial protocols, the standard approach looks like this: Weeks 1 to 4: 1 mg once weekly Weeks 5 to 8: 2 mg once weekly Weeks 9 to 12: 4 mg once weekly Weeks 13 to 16: 8 mg once weekly Weeks 17 onward: 12 mg once weekly (if tolerated) That is a minimum 16 to 20 week ramp-up to reach the maximum dose, compared to a similar timeline for Ozempic
Psychological benefits directly tied to weight loss, such as improved body image and physical capability, persist as long as the weight loss is maintained
Takikawa, M., Kurimoto, Y
These reactions usually appear within hours of injection and resolve within a few days
The MHRA-approved indications for these medications are limited to type 2 diabetes mellitus and, for certain formulations, obesity management in adults with specific BMI thresholds as detailed in their SmPCs
Full details of comparison analyses are provided in Supplementary Information
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