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Market Growth and Pressure to Expand Access The GLP1 weight loss market in South Africa brought in around R989 million in 2024

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What we know: The same total amount reaches your bloodstream - Clinical trial data confirmed equivalent overall absorption (AUC and Cmax) across all three sites Yet reported side effect rates differed substantially - Thigh showed roughly half the nausea rate of abdomen despite identical systemic exposure Possible explanations include differences in absorption rate (even if total absorption is equal), local tissue effects at the injection site, or simply statistical variation in a relatively small study

2 This is a cost-effectiveness recommendation, not a safety threshold: private prescriptions have no equivalent cap