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In biological systems, over 95% of circulating native IGF-1 is sequestered in ternary complexes with IGF binding proteins (primarily IGFBP-3) and the acid-labile subunit (ALS), meaning only a small free fraction is available to activate IGF-1R at any given time

(PubMed) Carroll D, Ring C, Suter M, Willemsen G

NICE obesity guidance (CG189) recommends multicomponent interventions addressing diet, physical activity, and behaviour change as first-line management

In rats receiving ISO therapy, WSLEt pretreatment dramatically lowers the levels of lipid peroxides