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It is important to mention that the research team took their experimental procedures a step further in order to define the relationship between Dihexa and the PI3K/AKT signaling pathway, wortmannin, a PI3K inhibitor, was administered to the mice intragastrically to detect the number of neuronal cells and inflammatory factors present
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However, mass spectrometry (MS) techniques have recently allowed the characterization of HSA modified by AX in serum from subjects under oral AX treatment 26,29 , having previously been performed for other BLs (benzylpenicillin (BP), flucloxacillin and piperacillin) 30,31,32,33,34