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Variants in the CaSR (calcium-sensing receptor) gene increase the risk of kidney stones due to the association between calcium binding to oxalate to form stones

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Additional insight comes from a meta-analysis of cannabinoid use in chronic pain, which documented cognitive adverse events including disorientation, memory impairment, and confusion

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It can also support skin healing and decrease eczema and psoriasis symptoms

Diabetics often have trouble absorbing larger doses of B12 all at once, so its generally best to take smaller doses more often