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Native IGF-1 has very high affinity for these binding proteins, with over 99% of circulating IGF-1 bound to IGFBPs, very IGFBP-3

If the TrxR1-, Gsr-, and Met-driven disulfide reductase systems play distinct roles in signaling and redox homeostasis, then it might be possible to target these pathways to selectively impact specific signaling activities versus homeostatic activities

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

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